Why Prednisone Causes Weight Gain

Prednisone is well-known for causing noticeable weight gain, especially during long-term use. This side effect is largely due to how the steroid alters your metabolism, increases your appetite, and causes fluid retention.

The most common areas people notice weight gain include:

• The face (“moon face”)
• Abdomen
• Back of the neck
• Midsection and upper back

This gain can feel frustrating and discouraging, but there are practical ways to manage it.

How Prednisone Affects Your Body

Prednisone mimics cortisol, a stress hormone that regulates metabolism and immune response. When taken in higher doses, it can:

• Slow your metabolism
• Increase blood sugar levels
• Promote fat storage
• Trigger cravings and appetite spikes

Water retention is another contributor. Prednisone causes your body to hold onto sodium and lose potassium, leading to bloating and puffiness.

Tips to Help Minimize Weight Gain

1. Watch Portion Sizes:
   You may feel hungrier than usual — listen to your body, but don’t let the increased appetite control your decisions.
2. Choose Low-Sodium Foods:
   Reduce salt intake to manage water retention and bloating.
3. Stay Active:
   Even gentle movement like walking or stretching can help balance your metabolism.
4. Eat More Protein and Fiber:
   These nutrients keep you full longer and support muscle retention.
5. Hydrate Consistently:
   Drinking water helps flush excess sodium and can reduce bloating.
6. Sleep Matters:
   Lack of rest can increase cortisol levels even more, worsening weight gain and cravings.

Managing Expectations

Even with the best strategies, you may still notice changes in your body while taking prednisone. That’s normal. Focus on what you can control and be kind to yourself — many of these effects reverse once your dosage lowers or the medication is stopped.

When to Ask for Help

If the weight gain is rapid, emotionally distressing, or impacting your overall health, speak with your doctor. They may consider dose adjustments or supportive therapies.

Final Thoughts

Weight gain from prednisone is common, but it doesn’t have to take over your life. By staying aware and making small, healthy adjustments, you can reduce its impact and feel more in control.